Author

Ramya Billur

University of PennsylvaniaORCID 0000-0002-8677-0801Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Ben E. BlackiD· 2 shared Andrea SorannoiD· 1 shared Andreas G. LadurneriD· 1 shared Bryan A. GibsoniD· 1 shared Elizabeth VillaiD· 1 shared Emily S. Smith-Pillet· 1 shared Huabin ZhouiD· 1 shared Jan HuertasiD· 1 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersCancer Biology

Ben E. BlackORCID

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Author profile →

3 papers

Recent·Most cited

Multi-scale structure of chromatin condensates rationalizes phase separation and material properties

Huabin Zhou, Jan Huertas, Maria Julia Maristany, Kieran O. Russell, June Ho Hwang, Run-Wen Yao, Nirnay Samanta, Joshua Hutchings, Ramya Billur, Momoko Shiozaki, Xiaowei Zhao, Lynda K. Doolittle, Bryan A. Gibson, Andrea Soranno, Margot Riggi, , Michael K. Rosen

The paper investigates the structure of chromatin condensates across scales and shows how nucleosome arrangement and histone interactions influence their physical properties.

Science · Dec 4, 2025Peer-reviewedBiophysics

A Population-Specific PARP1 Gene Variation Modulates PARP Trapping

Jin Cai, Ramya Billur, Michael S. Cohen, Andreas G. Ladurner, Ben E. Black

The paper shows a population-specific PARP1 gene variant enhances the efficacy and toxicity of the PARPi drug talazoparib by altering its mechanism of action.

bioRxiv · Nov 11, 2025 · PreprintCancer Biology

A PARP2-specific active site alpha-helix melts to permit DNA damage-induced enzymatic activation

Emily S. Smith-Pillet, Ramya Billur, Marie-France Langelier, Tanaji T. Talele, John M. Pascal, Ben E. Black

This study identifies structural differences in PARP1 and PARP2 activation mechanisms, showing that PARP2 requires an active site alpha-helix to be unfolded for DNA damage-induced activation, unlike PARP1.

Molecular Cell · Jan 30, 2025Peer-reviewedBiochemistry