Author

Emily S. Smith-Pillet

University of Pennsylvania

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

Ben E. BlackiD· 1 shared John M. PascaliD· 1 shared Marie-France LangelieriD· 1 shared Ramya BilluriD· 1 shared Tanaji T. TaleleiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

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5 top collaborators · 10 mutual co-author links

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1 shared paperBiochemistry

Ben E. BlackORCID

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1 paper

Recent·Most cited

BiochemistryMolecular CellPeer-reviewedJan 30, 2025

A PARP2-specific active site alpha-helix melts to permit DNA damage-induced enzymatic activation

Emily S. Smith-Pillet, Ramya Billur, Marie-France Langelier…·Ben E. Black

This study identifies structural differences in PARP1 and PARP2 activation mechanisms, showing that PARP2 requires an active site alpha-helix to be unfolded for DNA damage-induced activation, unlike PARP1.

11 citationstop 4%

protein structureexperimental assay

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