Author

Chelsea N. Fries

Duke UniversityORCID 0000-0002-2724-430XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Organism:non-human primate· 1 Research Focus:protein design· 1 Assay:protein structure· 1

Frequent Co-Authors

Adam J. Wargacki· 1 shared Andrew J. BorstiD· 1 shared Benjamin James Cossette· 1 shared Connor WeidleiD· 1 shared Corrine A. NiefiD· 1 shared Elizabeth J. CurvinoiD· 1 shared Emily F. RoeiD· 1 shared Genevieve G. FoudaiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

Adam J. Wargacki

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintOct 28, 2026

Discovering and designing multistate protein assemblies

Chelsea N. Fries, Samuel W. K. Tipps, Adam J. Wargacki…·Neil P. King

This paper designs protein assemblies that switch between structural states using engineered interfaces, demonstrating temperature-responsive transitions from capsids to 2D arrays.

DOI 10.64898/2026.10.26.762030

protein structureexperimental assay

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BioengineeringbioRxivPreprintOct 5, 2026

Designed nanofiber immunogens prime antibody responsesto diverse conformations of the HIV-1 fusion peptide

Chelsea N. Fries, Jui-Lin Chen, Nicole L. Votaw…·Joel H. Collier

This paper introduces a designed nanofiber immunogen platform that primes antibodies with increased conformational tolerance toward HIV-1 fusion peptide, showing efficacy in mice and infant non-human primates.

DOI 10.64898/2026.10.02.756244

mousenon-human primate

𝕏 PostBluesky