Author

Justin M. Fear

National Institutes of HealthORCID 0000-0002-2732-449XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Developmental Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Organism:Drosophila· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:machine learning (classical)· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Brian OliveriD· 2 shared Aaron W. Hummel· 1 shared Brenda A. Peterson· 1 shared Brian J. GallettaiD· 1 shared Camila C. AvelinoiD· 1 shared Carolina A. MendonçaiD· 1 shared David G. Schwark· 1 shared David Nicholl· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersDevelopmental Biology

Brian OliverORCID

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Author profile →

3 papers

Recent·Most cited

A novel mechanistic framework for precise sequence replacement using reverse transcriptase and diverse CRISPR-Cas systems

Y. Bill Kim, Elizabeth B. Pierce, Michael Brown, Brenda A. Peterson, Derek Sanford, Justin M. Fear, David Nicholl, Ellyce San Pedro, Grace M. Reynolds, Joanne E. Hunt, David G. Schwark, Sathya Jali, Nathaniel D. Graham, Zoe Cesarz, Tracey A. Lincoln Chapman, , Aaron W. Hummel

This paper introduces REDRAW, a novel DNA editing method using reverse transcriptase and type V CRISPR-Cas systems, enabling broader sequence replacement beyond type II systems.

bioRxiv · Dec 13, 2022 · PreprintMolecular Biology

Dynamic Sex Chromosome Expression in Drosophila Male Germ Cells

Sharvani Mahadevaraju, Justin M. Fear, Miriam Akeju, Brian J. Galletta, Mara Maria Lisboa Santana Pinheiro, Camila C. Avelino, Diogo Cavalcanti Cabral-de-Mello, Katie Conlon, Stefania Dell’Orso, Zelalem Demere, Kush Mansuria, Carolina A. Mendonça, Octavio Manuel Palacios-Gimenez, Eli Ross, Max E Savery, , Brian Oliver

The paper shows that X and 4th chromosomes are inactivated while Y chromosomes are active in Drosophila primary spermatocytes using single-cell RNA-Seq.

Nature Communications · Feb 9, 2021Peer-reviewedDevelopmental Biology

Reconstruction of Gene Regulatory Networks by integrating biological model and a recommendation system

Yijie Wang, Justin M. Fear, Isabelle Berger, Hangnoh Lee, Brian Oliver, Teresa M. Przytycka

The paper introduces NetREX-CF, a method combining collaborative filtering and sparse network component analysis to reconstruct gene regulatory networks, outperforming existing methods.

Lecture notes in computer science · Jan 1, 2020Peer-reviewedBioinformatics