Hangnoh Lee

This study identifies ferroptosis in embryonic lung and kidney progenitor cells, showing its role in organ morphogenesis through genetic manipulation of Gpx4.

This study shows that isoflurane anesthesia and surgery cause chronic sex-dependent neurological issues in mice, linked to changes in brain transcriptomes and circulating extracellular vesicles.

This study shows that isoflurane anesthesia and surgery worsen lipid dysregulation and neural dysfunction in APOE4 mice, leading to neurological impairments.

This study shows isoflurane and surgical stress cause age-dependent cardiac metabolic and structural changes leading to cardiomyopathy.

This study shows that IRBIT suppresses RNR activity in intestinal stem cell progeny to drive differentiation into enterocytes, maintaining gut tissue integrity in Drosophila.

The paper introduces NetREX-CF, a method combining collaborative filtering and sparse network component analysis to reconstruct gene regulatory networks, outperforming existing methods.

The paper investigates non-canonical dosage compensation on the Drosophila X chromosome, showing that repressive chromatin domains contribute to gene expression balance in males.

The paper investigates how gene copy number, dosage compensation, and expression noise interact in Drosophila, finding that one dose genes show higher expression variability and that dosage compensation increases noise in autosomal genes but not X-linked genes.

NetREX constructs context-specific regulatory networks by integrating expression data and context-agnostic networks, showing improved biological consistency in Drosophila data.

The paper examines gene dosage effects in Drosophila deficiency heterozygotes, finding varied transcriptional responses and minimal long-range regulatory impacts from breakpoints.