BiochemistryCell Communication and SignalingPeer-reviewed
ZNF638 represses the transcription of HBV closed circular DNA involving HUSH complex-mediated histone modifications of epigenetic silencing
Sifan Meng, Xiaowei Sha, Guoyan Zhang…·Wei Ding
This study identifies ZNF638 as a host factor that represses HBV transcription by recruiting the HUSH complex to induce H3K9me3 histone modifications, thereby silencing cccDNA and reducing viral propagation.
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