ZNF638 represses the transcription of HBV closed circular DNA involving HUSH complex-mediated histone modifications of epigenetic silencing
Sifan Meng, Xiaowei Sha, Guoyan Zhang, Binwei Duan, Jing Wang, Yang Si, Feng Li, Qiong Wu, Shan Cheng, Wei Ding
This study identifies ZNF638 as a host factor that represses HBV transcription by recruiting the HUSH complex to induce H3K9me3 histone modifications, thereby silencing cccDNA and reducing viral propagation.
Cell Communication and Signaling · Feb 13, 2026Peer-reviewedBiochemistry