Author

Wenrui Guo

University of CambridgeORCID 0000-0002-2750-5493Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:gene regulatory network inference· 1 Assay:protein sequence· 1

Frequent Co-Authors

Frank M. McCaughaniD· 2 shared Namshik HaniD· 2 shared Ali Önder YildirimiD· 1 shared Alice Chernaik· 1 shared Anne HilgendorffiD· 1 shared Christina Gabriel· 1 shared Daniel KottmanniD· 1 shared Daniella Black· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersCancer Biology

Frank M. McCaughanORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintSep 18, 2026

Carcinogen-induced preinvasive human squamous lung cancer is characterised by a novel atypical basal cell state and presents opportunities for chemoprevention

Wenrui Guo, Holly A. R. Giles, Alice Chernaik…·Frank M. McCaughan

This study develops a human model of early squamous lung cancer induced by a carcinogen, identifies a novel atypical basal cell state, and shows that capivasertib prevents and reverses the abnormal phenotype.

DOI 10.64898/2026.09.17.748423

humanbulk RNA-seq

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BioinformaticsCommunications ChemistryPeer-reviewedDec 12, 2025

Utilising multi-modal data-driven network analysis to identify monotherapy and combinational therapy targets in SOX2-dependent squamous cell lung cancer

Woochang Hwang, Daniel Kottmann, Wenrui Guo…·Namshik Han

The paper develops a computational pipeline to identify drug targets for SOX2-dependent lung cancer using multi-modal data and validates them in vitro.

2 citations

humanbulk RNA-seq

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