Ali Önder Yildirim

This study develops a human model of early squamous lung cancer induced by a carcinogen, identifies a novel atypical basal cell state, and shows that capivasertib prevents and reverses the abnormal phenotype.

This study uses single-cell and spatial transcriptomics to identify structural cell circuits in BOS lungs and their spatial organization during airway obliteration.

This study identifies aberrant cell populations in RAS lungs using snRNA-seq and histology, revealing a fibrotic niche composed of specific cell types with potential therapeutic targets.

This study analyzes lung epithelial cells across the lifespan in mice, identifying age-related declines in regeneration linked to inflammation and epigenetic changes.

This paper introduces a generative AI framework for designing and fabricating disease-specific lung microtissues using 3D imaging and bioprinting.

The paper shows that alveolar macrophages recruit neutrophils to sites of nanoparticle deposition in the lung through motility, phagocytosis, and cytokine release.

This study identifies the eATP/P2X7R axis as a driver of nanoparticle-induced neutrophil recruitment in the pulmonary microcirculation using intravital microscopy in mice.

This study uses single-cell RNA-sequencing to analyze how different nanomaterials affect lung inflammation in mice, identifying cell type-specific responses and mechanisms.

This study shows SARS-CoV-2 spike protein accumulates in the skull-meninges-brain axis, causing brain cell death and long-term neurological effects.

This study identifies NFATC4 as a regulator of myofibroblast activity through phosphoproteomic analysis of fibroblast mechanosensing on stiffness-modulated substrates.