Author

Frank M. McCaughan

University of CambridgeORCID 0000-0002-8012-7524Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:gene regulatory network inference· 1 Assay:protein sequence· 1

Frequent Co-Authors

Namshik HaniD· 2 shared Wenrui GuoiD· 2 shared Ali Önder YildirimiD· 1 shared Alice Chernaik· 1 shared Anne HilgendorffiD· 1 shared Christina Gabriel· 1 shared Daniel KottmanniD· 1 shared Daniella Black· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersCancer Biology

Namshik HanORCID

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2 papers

Recent·Most cited

Carcinogen-induced preinvasive human squamous lung cancer is characterised by a novel atypical basal cell state and presents opportunities for chemoprevention

Wenrui Guo, Holly A. R. Giles, Alice Chernaik, Yasin Memari, Joanna Xie, Daniella Black, Anne Hilgendorff, Christina Gabriel, Ali Önder Yildirim, Helen Davies, Martin Goddard, Lauren D’Sa, Otmar Schmid, Serena Nik‐Zainal, Namshik Han, Frank M. McCaughan

This study develops a human model of early squamous lung cancer induced by a carcinogen, identifies a novel atypical basal cell state, and shows that capivasertib prevents and reverses the abnormal phenotype.

bioRxiv · Sep 18, 2026 · PreprintCancer Biology

Utilising multi-modal data-driven network analysis to identify monotherapy and combinational therapy targets in SOX2-dependent squamous cell lung cancer

Woochang Hwang, Daniel Kottmann, Wenrui Guo, Méabh MacMahon, Lúcia L. Correia, Sherine Ahmed, Rebecca Harris, Frank M. McCaughan, Namshik Han

The paper develops a computational pipeline to identify drug targets for SOX2-dependent lung cancer using multi-modal data and validates them in vitro.

Communications Chemistry · Dec 12, 2025Peer-reviewedBioinformatics