Opposing CTCF and GATA4 activities set the pace of chromatin topology remodeling during cardiomyogenesis
Silvia Becca, Sara Bianchi, Elisa M. Hahn, Kirsten E Snijders, Lukasz Truszkowski, Anna Křepelová, Francesco Neri, Davide Cacchiarelli, Sasha Mendjan, Elisa Balmas, Alessandro Bertero
The paper shows that CTCF and GATA4 have opposing roles in chromatin remodeling during cardiomyogenesis, with CTCF inhibiting and GATA4 promoting topological changes.
bioRxiv · Oct 7, 2025 · PreprintMolecular Biology