Sasha Mendjan

This study uses a human cardioid injury platform to investigate immune-ECM-cardiomyocyte interactions in fetal cardiac repair, identifying key signaling pathways and cellular behaviors involved in regeneration.

This study shows hyaluronan drives cavity formation, cell identity, and function in human cardioids through mechanical and bioscaffolding roles.

The paper shows that CTCF and GATA4 have opposing roles in chromatin remodeling during cardiomyogenesis, with CTCF inhibiting and GATA4 promoting topological changes.

This paper develops a multi-chamber cardioid platform to study human heart development and defects by generating compartment-specific gene expression, morphology, and function.

This study identifies ZFP462's role in restricting endodermal gene expression by targeting transposon-derived enhancers and modulating histone methylation in mouse embryonic stem cells.

This paper establishes self-organizing cardioids from human pluripotent stem cells that form chamber-like structures and identifies signaling pathways governing their development.

The paper shows that RBPMS controls mRNA translation in pluripotent hESCs to preset cardiac fate competence, which is critical for cardiogenesis.