Genetic background and transient prenatal disruption of vitamin A signaling determine susceptibility to airway hyperresponsiveness in mice
Takehiro Otoshi, Ayyappa Kumar Sista Kameshwar, Benjamin D. Kotton, Yoshinori Seki, Zachary Cardell, Xiangyi Ke, Yuta Matsuno, Pooja Rajaram, Youn‐Kyung Kim, Sarah M. Sharpton, Loredana Quadro, Wellington Veras Cardoso, Masako Suzuki
The paper shows that genetic background and prenatal vitamin A disruption influence airway hyperresponsiveness in mice through TGFβ-activating mesenchymal cells.
bioRxiv · Oct 31, 2025 · PreprintDevelopmental Biology