Author

Xiangyi Ke

Columbia University Irving Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Developmental Biology· 1

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Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Wellington Veras CardosoiD· 2 shared Adolfo García‐SastreiD· 1 shared Andrea CalifanoiD· 1 shared Ayyappa Kumar Sista KameshwariD· 1 shared Benjamin D. Kotton· 1 shared Brooke DirviniD· 1 shared Charles KaraniD· 1 shared Dianbo Cao· 1 shared

Activity by Year

2025-2025 · peak 2/yr

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10 top collaborators · 31 mutual co-author links

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2 shared papersDevelopmental Biology

Wellington Veras CardosoORCID

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2 papers

Recent·Most cited

Genetic background and transient prenatal disruption of vitamin A signaling determine susceptibility to airway hyperresponsiveness in mice

Takehiro Otoshi, Ayyappa Kumar Sista Kameshwar, Benjamin D. Kotton, Yoshinori Seki, Zachary Cardell, Xiangyi Ke, Yuta Matsuno, Pooja Rajaram, Youn‐Kyung Kim, Sarah M. Sharpton, Loredana Quadro, Wellington Veras Cardoso, Masako Suzuki

The paper shows that genetic background and prenatal vitamin A disruption influence airway hyperresponsiveness in mice through TGFβ-activating mesenchymal cells.

bioRxiv · Oct 31, 2025 · PreprintDevelopmental Biology

Identification and Targeting of Regulators of SARS-CoV-2-Host Interactions in the Airway Epithelium.

Brooke Dirvin, Heeju Noh, Lorenzo Tomassoni, Dianbo Cao, Yizhuo Zhou, Xiangyi Ke, Jun Qian, Sonia Jangra, Michael Schotsaert, Adolfo García‐Sastre, Charles Karan, Andrea Califano, Wellington Veras Cardoso

The paper identifies master regulator modules in human airway epithelial cells reprogrammed by SARS-CoV-2 and finds 11 drugs that reverse these signatures.

Science Advances · May 16, 2025Peer-reviewedCell Biology