Masako Suzuki

This study shows that MLL3's tumor suppressor role in breast cancer depends on its adaptor function, not its catalytic activity.

The paper maps single-cell gene expression and chromatin accessibility changes in the mouse brain across reproductive transitions, identifying hormone-driven neurogenesis and disease-relevant gene regulation.

The paper integrates multi-omic QTLs and predictive models to identify regulatory variants in CD4+ T cells and their role in immune-related GWAS loci.

This study shows that Egr1 overexpression induces sex-specific changes in neuronal chromatin, gene expression, and behavior in female rodents, mimicking high-oestrogenic phases and affecting hormone-depleted females.

The paper shows that genetic background and prenatal vitamin A disruption influence airway hyperresponsiveness in mice through TGFβ-activating mesenchymal cells.

ERSAtool provides an intuitive R/Shiny interface for RNA-seq analysis, reducing technical barriers and supporting educational use with comprehensive reporting.

The paper shows how early-life stress and ovarian hormones affect transcriptional regulation in the nucleus accumbens, leading to sex-specific responses to cocaine in mice.

This study shows prenatal vitamin D deficiency changes immune cell proportions in offspring by altering hematopoietic stem cell transcriptional properties and confirms maternal vitamin D levels affect cord blood immune profiles.

The paper develops NuHash, a method for multiplexing snATAC-seq using oligonucleotide-conjugated antibodies, achieving high demultiplexing accuracy with human and mouse samples.

The paper evaluates three ATAC-seq protocols for neuronal chromatin accessibility analysis in mouse and human brains, showing consistent results across freezing methods and highlighting challenges in human post-mortem tissue.

The paper evaluates epigenetic methods using reference materials, finding high concordance between assays and differences in performance across platforms.

This study shows that gene expression distributions in cancer data are often non-Normal, and using this information improves survival classification in cancer patients.

This paper describes a protocol for efficient CRISPR-mediated genomic editing in Epstein-Barr virus-transformed lymphoblastoid B cells using ssODN, achieving 20% successful editing and identifying structural mutations missed by targeted sequencing.

The paper shows that estimating cell subtype proportions from functional genomic data improves interpretation of human phenotypic associations by revealing cellular events.

The paper optimizes library preparation and sequencing for whole genome bisulphite sequencing on the Illumina HiSeq X system, eliminating an artefact affecting several percent of reads.

MAD-seq detects low-level mosaic chromosomal aneuploidy using a new sequencing assay and analysis method, revealing previously unrecognized aneuploidy in public datasets.

This study investigates how Toxoplasma gondii infection alters host transcriptional regulation by redistributing AP-1 transcription factor binding, leading to changes in chromatin accessibility and gene expression.

This study identifies epigenetic dysregulation in ectodermal cells of individuals with ASD born to older mothers, suggesting a potential role for epigenetic changes in ASD pathogenesis.