Dissociation of the nuclear basket triggers chromosome loss in aging yeast
Mihailo Mirkovic, Jordan McCarthy, Anne C. Meinema, Julie Parenteau, Sung Sik Lee, Sherif Abou Elela, Yves Barral
This study shows that nuclear basket displacement in aging yeast causes chromosome loss by disrupting pre-mRNA quality control and asymmetric segregation.
eLife · Oct 30, 2025Peer-reviewedCell Biology