Yves Barral

Low-affinity binding motif in microtubule plus-end condensates specializes microtubule function

The paper identifies a low-affinity KDK motif in Kar9 that specializes +TIP body function by modulating microtubule dynamics through multivalent interactions with Bik1.

Plasticity of genetic regulation during cellular learning

This study investigates the genetic basis of cellular learning in budding yeast, showing it arises from a dynamic, redundant network with variable gene contributions and broad functional integration.

RNAi-based discrimination of exogenous DNA by mitotic heterochromatin in fission yeast

This study identifies a mechanism in fission yeast that discriminates exogenous DNA by converting it into heterochromatin via RNAi, leading to its unequal partitioning and elimination during mitosis.

Dissociation of the nuclear basket triggers chromosome loss in aging yeast

This study shows that nuclear basket displacement in aging yeast causes chromosome loss by disrupting pre-mRNA quality control and asymmetric segregation.

A protein condensation network contextualises cell fate decisions

The paper identifies a protein condensation network in yeast that integrates internal and external signals to regulate cell fate decisions during senescence and pheromone response.

A fluid droplet harvests the force generated by shrinking microtubules in living cells

The paper shows that biomolecular condensates in budding yeast capture forces from shrinking microtubules to move the mitotic spindle.

Mitotic chromosome condensation resets chromatin to maintain transcriptional homeostasis

The paper shows that mitotic chromosome condensation resets transcriptional homeostasis by preventing unscheduled gene expression and transcriptional drift in the subsequent interphase.