Neoantigens drive adoptively transferred CD8 T cells to long-lived effectors mediated by lymph node trafficking
Megen C Wittling, Amalia M. Rivera-Reyes, Megan M. Wyatt, Aubrey S. Smith, Anna C. Cole, Guillermo O. Rangel Rivera, Michael B. Ware, Ayana T. Ruffin, Soundharya Kumaresan, Frances J. Bennett, Gregory B. Lesinski, Chrystal Mary Paulos, Hannah M. Knochelmann
This study shows that neoantigen-reactive T cells achieve long-term antitumor effects through lymph node trafficking, enhancing their persistence and efficacy.
bioRxiv · Apr 18, 2025 · PreprintCancer Biology