Author

Gregory B. Lesinski

Emory UniversityORCID 0000-0002-8787-7678Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Ayana T. RuffiniD· 2 shared Chrystal Mary PaulosiD· 2 shared Olatunji Boladale AleseiD· 2 shared Vaunita C ParihariD· 2 shared ADITHYA K. YADALAMiD· 1 shared Alyssa M. KrasinskasiD· 1 shared Amalia M. Rivera-ReyesiD· 1 shared Amandeep Ahluwalia· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

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2 shared papersCancer Biology

Ayana T. RuffinORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Immune determinants of leuprolide-associated cardiovascular risk in prostate cancer

Tuisha Gupta, Fanyuan Zeng, Marguerite Li, Ian Moore, Vaunita C Parihar, ADITHYA K. YADALAM, Amandeep Ahluwalia, Rendy Javier Chaparro Reyes, Yujie Chen, Jacklyn Hammons, Emily Chung, Haitong Xu, Sonia Mecorapaj, Michelle Lu, Ryan Han, , Kiranj Kishor Chaudagar

This study identifies immune programs linked to leuprolide-associated cardiovascular risk in prostate cancer patients through spatial transcriptomic and immune-stromal profiling.

bioRxiv · Oct 8, 2026 · PreprintImmunology

MetScore and classical-basal subtype intersect to define chemotherapy response and tumor microenvironment architecture in pancreatic ductal adenocarcinoma

Raymond E. Preston, Hongyu Huang, Margaret A Hall, Udhayvir Singh Grewal, Kawther Abdilleh, Sudheer Doss, Richard A. Moffitt, Olatunji Boladale Alese, Gregory B. Lesinski, Jesse Stone Handler

The paper integrates MetScore with classical-basal subtype to better explain PDAC metastasis, prognosis, treatment response, and tumor microenvironment than a single-axis model.

bioRxiv · Sep 17, 2026 · PreprintCancer Biology

Neoantigens drive adoptively transferred CD8 T cells to long-lived effectors mediated by lymph node trafficking

Megen C Wittling, Amalia M. Rivera-Reyes, Megan M. Wyatt, Aubrey S. Smith, Anna C. Cole, Guillermo O. Rangel Rivera, Michael B. Ware, Ayana T. Ruffin, Soundharya Kumaresan, Frances J. Bennett, Gregory B. Lesinski, Chrystal Mary Paulos, Hannah M. Knochelmann

This study shows that neoantigen-reactive T cells achieve long-term antitumor effects through lymph node trafficking, enhancing their persistence and efficacy.

bioRxiv · Apr 18, 2025 · PreprintCancer Biology

High-Dimensional Protein Analysis Uncovers Distinct Immunological and Stromal Signatures Between Primary and Metastatic Pancreatic Ductal Adenocarcinoma

Emily R. Greene, Natalie K. Horvat, Deon Bryant Doxie, Vaunita C Parihar, Jayden Kim, Cameron J. Herting, Erin E. Grundy, Ayana T. Ruffin, Alyssa M. Krasinskas, Shishir Kumar Maithel, Juan Manuel Sarmiento, Mihir Maheshkumar Shah, Mohammad Y. Zaidi, Maria Diab, Olatunji Boladale Alese, , Gregory B. Lesinski

bioRxiv · Apr 18, 2025 · PreprintCancer Biology