Chrystal Mary Paulos

Confined T cell migration controls programmed cell death 1 expression

The paper shows that confined T cell migration through pores reduces programmed cell death 1 expression via ubiquitin-mediated degradation, enhancing T cell function and correlating with disease outcomes in melanoma.

Neoantigens drive adoptively transferred CD8 T cells to long-lived effectors mediated by lymph node trafficking

This study shows that neoantigen-reactive T cells achieve long-term antitumor effects through lymph node trafficking, enhancing their persistence and efficacy.

High-Dimensional Protein Analysis Uncovers Distinct Immunological and Stromal Signatures Between Primary and Metastatic Pancreatic Ductal Adenocarcinoma