Author

Megen C Wittling

Emory UniversityORCID 0000-0002-3631-4955Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:CITE-seq· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Chrystal Mary PaulosiD· 2 shared Megan M. WyattiD· 2 shared Alexander Shih· 1 shared Amalia M. Rivera-ReyesiD· 1 shared Anna C. ColeiD· 1 shared Aubrey S. SmithiD· 1 shared Ayana T. RuffiniD· 1 shared Frances J. BennettiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersImmunology

Chrystal Mary PaulosORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Confined T cell migration controls programmed cell death 1 expression

Yunus Alapan, Jaehoon Kim, Kiyoon Min, Alexander Shih, Samuel N. Lucas, Taehee Yoon, Paul A. Archer, Heather K. Lin, Ruby Freeman, Megen C Wittling, Megan M. Wyatt, Chrystal Mary Paulos, Sarwish Rafiq, Susan Napier Thomas

The paper shows that confined T cell migration through pores reduces programmed cell death 1 expression via ubiquitin-mediated degradation, enhancing T cell function and correlating with disease outcomes in melanoma.

bioRxiv · Jul 9, 2026 · PreprintImmunology

Neoantigens drive adoptively transferred CD8 T cells to long-lived effectors mediated by lymph node trafficking

Megen C Wittling, Amalia M. Rivera-Reyes, Megan M. Wyatt, Aubrey S. Smith, Anna C. Cole, Guillermo O. Rangel Rivera, Michael B. Ware, Ayana T. Ruffin, Soundharya Kumaresan, Frances J. Bennett, Gregory B. Lesinski, Chrystal Mary Paulos, Hannah M. Knochelmann

This study shows that neoantigen-reactive T cells achieve long-term antitumor effects through lymph node trafficking, enhancing their persistence and efficacy.

bioRxiv · Apr 18, 2025 · PreprintCancer Biology