Darrell O. Ricke

This paper provides a comprehensive guide for quality control metrics and mitigation strategies for 11 epigenetics and transcriptomics assays to improve exposure signature discovery.

The paper identifies HTS barcode contamination and introduces a tool, TallyBarcodes, to detect it in sequencing data.

This paper introduces a method for kinship estimation using large SNP panels, resolving parent-sibling relationships and distinguishing degrees of kinship.

The paper proposes computational methods to identify low variability pathogen targets for medical countermeasure development using variation analysis.

The paper presents models for SNP-based identification and mixture analysis across ethnicities, kinship, and admixture using in silico datasets.

The paper introduces three methods to estimate individual DNA contributions in forensic SNP mixtures using HTS/MPS data.

TranslucentID identifies contributors in saturated DNA SNP mixtures by desaturating them using minor allele ratios, improving detection confidence in forensic analysis.

The paper creates a reference dataset of 11 million SNP profiles for DNA forensics applications across diverse ethnicities, kinship, and admixture.

GrigoraSNPs optimizes SNP calling in DNA forensics by improving runtime efficiency for high-throughput sequencing data.

The paper introduces an open-source framework for integrating heterogeneous biomedical data from diverse sources to support scalable analysis across personal, community, and population levels.

The paper introduces a new formula for efficiently calculating P(RMNE) in DNA mixture analysis to handle larger SNP panels without computational artifacts.

The paper explores using commercial activity tracking watches to continuously monitor electrodermal activity for individuals experiencing vasomotor symptoms, aiming to improve upon diary-based tracking methods.

The paper introduces the Plateau method to deconvolve DNA mixtures into individual sub-profiles using SNP data without reference profiles, detecting contributors as low as 1/200 in concentration.

FastID rapidly compares DNA forensic profiles using SNP loci, achieving fast search times on standard hardware.

The paper presents a GPU-accelerated DNA mixture analysis method using linear algebra, enabling fast comparison of DNA samples by leveraging matrix multiplication.

The paper proposes using Bluetooth Low Energy to integrate heterogeneous biosensors into an open data framework for better health data management and analysis.

The paper demonstrates that high-throughput sequencing can accurately profile CODIS STR loci, achieving 99.6% allele calling accuracy and identifying novel alleles.

The paper introduces a divergence model of protein evolution to interpret sequence variants by analyzing evolutionary conservation and its implications for protein function.