This study shows hypoalbuminemia reduces fibrin clot porosity and impairs fibrinolysis in nephrotic syndrome, suggesting albumin directly enhances fibrinolysis.

Journal of Thrombosis and Haemostasis · Oct 18, 2025Peer-reviewedPhysiology

Antithrombin, protein C and protein S: Genome and transcriptome wide association studies identify 7 novel loci regulating plasma levels

Yuekai Ji, Gerard Temprano‐Sagrera, Lori A. Holle, Allison Bebo, Jennifer A. Brody, Ngoc‐Quynh Le, Kadri Kangro, Michael R. Brown, Ángel Martínez-Pérez, Colleen M. Sitlani, Pierre Suchon, Marcus Edi Kleber, David B. Emmert, Ayse Bilge Ozel, Dre’Von A. Dobson, , Maria Sabater‐Lleal

Arteriosclerosis Thrombosis and Vascular Biology · Apr 27, 2023Peer-reviewedGenetic & Genomic Medicine

The plasma Factor XIII heterotetrameric complex structure: unexpected unequal pairing within a symmetric complex

Sneha Singh, Alexis Nazabal, Senthilvelrajan Kaniyappan, Jean‐Luc Pellequer, Alisa S. Wolberg, Diana Imhof, Johannes Oldenburg, Arijit Biswas

The paper determines the structure of the FXIII-A2B2 complex, revealing asymmetric subunit pairing critical for its assembly and activation.

Biomolecules · Nov 21, 2019Peer-reviewedMolecular Biology