Johannes Oldenburg

Vitamin K2 Limits Ferroptosis-Associated Lipid Peroxidation and Attenuates Aortic Valve Stenosis

This study shows vitamin K2 reduces ferroptosis-driven lipid peroxidation and slows aortic valve stenosis progression in both human and mouse models.

Engineered endothelial cell grafts form functional anastomoses and enable recruitment of intravenously delivered human T cells in CAM tumor models

This paper develops an endothelial graft-enhanced CAM tumor model to study T cell recruitment and activation in human cancer immunotherapy.

Evolutionary algorithms accelerate de novo design of potent Nectin-4-specific cancer biologics

This paper combines evolutionary algorithms with AI to design potent Nectin-4-specific cancer biologics, achieving high-affinity minibinders and functional reagents.

NKG7 is a stable marker of cytotoxicity across immune contexts and within the tumor microenvironment

The paper identifies NKG7 as a reliable and consistent marker of cytotoxicity across immune subsets and tissues, outperforming traditional markers like Granzyme B and Perforin.

Development of AI-designed protein binders for detection and targeting of cancer cell surface proteins

This paper develops AI-designed protein binders for cancer cell surface proteins, showing their effectiveness in detection and targeting through experimental validation and benchmarking of structure prediction models.

The plasma Factor XIII heterotetrameric complex structure: unexpected unequal pairing within a symmetric complex

The paper determines the structure of the FXIII-A2B2 complex, revealing asymmetric subunit pairing critical for its assembly and activation.