NeurosciencebioRxivPreprint
Upregulation of Trem2 expression occurs exclusively on microglial contact with plaques
Jack I. Wood, Eugenia Wong, Ridwaan Joghee…·Frances A. Edwards
The paper shows that Trem2 gene expression in microglia is upregulated only when they contact plaques, and this effect is reduced by the Trem2R47H mutation.
DOI 10.1101/2022.01.26.477873