Eugenia Wong

The KRAB-Zinc Finger protein ZKSCAN3 represses enhancers via embedded retrotransposons

This study shows ZKSCAN3 represses enhancers by targeting retrotransposons without forming heterochromatin, linking it to neurodevelopmental processes and schizophrenia.

Epigenetic restoration of differentiation competency via reversal of epiblast regionalisation

This study identifies histone modification fluctuations as a cause of PSC differentiation bias and presents a chemical chromatin restoration method to reverse it, restoring epiblast-like differentiation potential.

Upregulation of Trem2 expression occurs exclusively on microglial contact with plaques

The paper shows that Trem2 gene expression in microglia is upregulated only when they contact plaques, and this effect is reduced by the Trem2R47H mutation.