Author

Aya Balbaa

University College London

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Organism:mouse· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Assay:spatial transcriptomics· 2 Research Focus:benchmarking· 1 Research Focus:cell-cell communication· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Damian M. CummingsiD· 3 shared Frances A. EdwardsiD· 3 shared Jack I. WoodiD· 3 shared John HardyiD· 3 shared Jörg HanriederiD· 3 shared Sneha DesaiiD· 3 shared Dervis A. M. SalihiD· 2 shared Takshashila TripathiiD· 2 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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3 shared papersNeuroscience

Damian M. CummingsORCID

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3 papers

Recent·Most cited

Spatially Resolved Microglial Expression Around Aβ Plaques in Human Alzheimers Disease Tissue

Jack I. Wood, Georgia Ppasia, Paul Rolland-Du-Roscoat, Sneha Desai, Shamim Choudhury, Aya Balbaa, Daria Gavriouchkina, Modesta Blunskyte-Hendley, John Hardy, Damian M. Cummings, Dervis A. M. Salih, Jörg Hanrieder, Frances A. Edwards

The paper identifies gene expression changes in microglia around Aβ plaques in human Alzheimer's disease tissue and finds cross-species concordance with mouse data.

bioRxiv · Aug 29, 2025 · PreprintNeuroscience

Age- and amyloid-β-dependent initiation of neurofibrillary tau tangles: NLFTaum/h, an improved mouse model of Alzheimer's disease without mutations in MAPT

Sneha Desai, Jiongqiao La, Aya Balbaa, Elena Camporesi, Gunnar Brinkmalm, Kritika Goyal, Argyro Alatza, Jack I. Wood, Takshashila Tripathi, Sumi Bez, Nazar Stasyuk, Haady B. Hajar, Takashi Saito, Takaomi C. Saido, Henrik Zetterberg, , Frances A. Edwards

This paper introduces a new mouse model, NLFTaum/h, that shows ageing and amyloid-β can initiate tau pathology without MAPT mutations, revealing interactions between age, Aβ, and human tau.

bioRxiv · Nov 4, 2024 · PreprintNeuroscience

Upregulation of Trem2 expression occurs exclusively on microglial contact with plaques

Jack I. Wood, Eugenia Wong, Ridwaan Joghee, Aya Balbaa, Karina S. Vitanova, Alison VanSchoiack, Stefan-Laural J. Phelan, Francesca Launchbury, Sneha Desai, Takshashila Tripathi, Jörg Hanrieder, Damian M. Cummings, John Hardy, Frances A. Edwards

The paper shows that Trem2 gene expression in microglia is upregulated only when they contact plaques, and this effect is reduced by the Trem2R47H mutation.

bioRxiv · Jan 26, 2022 · PreprintNeuroscience