Author

Jingyi Yuan

Center for Life SciencesORCID 0000-0002-2850-1582Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

Frequent Co-Authors

Bailong XiaoiD· 2 shared Boxue TianiD· 2 shared Sijia LiuiD· 2 shared Xueming LiiD· 2 shared Xuzhong YangiD· 2 shared Chao LiniD· 1 shared Chenxi WangiD· 1 shared Heng ZhouiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersBiophysics

Bailong XiaoORCID

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2 papers

Recent·Most cited

BiophysicsbioRxivPreprintNov 17, 2025

A disease mutation reveals a non-swapped pore and rewired gating cycle of the mechanically activated PIEZO1 channel

Chenxi Wang, Ziying Zhang, Xuzhong Yang…·Bailong Xiao

This paper investigates the structural and functional changes in the PIEZO1-R2482H mutant, revealing a non-swapped pore and altered gating cycle that explain its heightened mechanosensitivity and slowed inactivation.

DOI 10.1101/2025.11.17.688653

humanstructural biology

NeurosciencebioRxivPreprintSep 28, 2023

Central pore-opening structure and gating of the mechanosensitive PIEZO1 channel

Sijia Liu, Xuzhong Yang, Xudong Chen…·Bailong Xiao

This study defines the structural states and curvature-based activation/inactivation mechanisms of PIEZO1 using a mutant and molecular dynamics simulations.

6 citations

experimental assay