Xueming Li

Sampling Mismatch and Correction for Ptychographic Single-Particle Analysis

This study identifies sampling mismatch in ptychographic single-particle analysis and shows that correcting it improves resolution by ~1.5 Å.

Electron counting enables cryo-electron ptychography for near-atomic-resolution cryo-electron microscopy

This paper introduces electron counting in cryo-electron ptychography to achieve near-atomic resolution for biological specimens, demonstrating 3.59 Å resolution for the T20S proteasome.

A disease mutation reveals a non-swapped pore and rewired gating cycle of the mechanically activated PIEZO1 channel

This paper investigates the structural and functional changes in the PIEZO1-R2482H mutant, revealing a non-swapped pore and altered gating cycle that explain its heightened mechanosensitivity and slowed inactivation.

Autolamellasomes: Linking Autophagy-Dependent ER Degradation to Whorled Lysosome Biogenesis

The paper identifies autolamellasomes as a form of ER remodeling mediating bulk ER degradation under mTOR inhibition, linking it to lysosomal membrane homeostasis and aging.

Central pore-opening structure and gating of the mechanosensitive PIEZO1 channel

This study defines the structural states and curvature-based activation/inactivation mechanisms of PIEZO1 using a mutant and molecular dynamics simulations.

Cryo-EM Structure of R-loop monoclonal antibody S9.6 in recognizing RNA:DNA hybrids

This study determines the cryo-EM structure of the S9.6 antibody Fab bound to RNA:DNA hybrids, revealing its recognition mechanism and binding specificity.

A particle-filter framework for robust cryoEM 3D reconstruction

This paper introduces a particle-filter algorithm for cryoEM to improve robustness and resolution in 3D reconstruction of macromolecules.