Author

Xuzhong Yang

Center for Life SciencesORCID 0000-0001-6654-0294Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

Frequent Co-Authors

Bailong XiaoiD· 3 shared Boxue TianiD· 2 shared Jinghui JiangiD· 2 shared Jingyi YuaniD· 2 shared Li WangiD· 2 shared Sijia LiuiD· 2 shared Xueming LiiD· 2 shared Chao LiniD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersNeuroscience

Bailong XiaoORCID

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3 papers

Recent·Most cited

BiophysicsbioRxivPreprintNov 17, 2025

A disease mutation reveals a non-swapped pore and rewired gating cycle of the mechanically activated PIEZO1 channel

Chenxi Wang, Ziying Zhang, Xuzhong Yang…·Bailong Xiao

This paper investigates the structural and functional changes in the PIEZO1-R2482H mutant, revealing a non-swapped pore and altered gating cycle that explain its heightened mechanosensitivity and slowed inactivation.

DOI 10.1101/2025.11.17.688653

humanstructural biology

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NeurosciencebioRxivPreprintSep 28, 2023

Central pore-opening structure and gating of the mechanosensitive PIEZO1 channel

Sijia Liu, Xuzhong Yang, Xudong Chen…·Bailong Xiao

This study defines the structural states and curvature-based activation/inactivation mechanisms of PIEZO1 using a mutant and molecular dynamics simulations.

6 citations

experimental assay

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NeuroscienceCell ReportsPeer-reviewedFeb 1, 2022

Tethering Piezo channels to the actin cytoskeleton for mechanogating via the E-cadherin-β-catenin mechanotransduction complex

Jing Wang, Jinghui Jiang, Xuzhong Yang…·Bailong Xiao

This paper identifies how Piezo1 channels are tethered to the actin cytoskeleton via the E-cadherin-β-catenin complex, enabling mechanogating through direct force transmission.

224 citationstop 1%

experimental assay

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