Bailong Xiao

ICFinder: ion channel identification and ion permeation residue prediction using protein language models

ICFinder uses protein language models to identify ion channels and predict permeation residues, outperforming existing methods and providing a public resource.

Mouse behavioral genomics identifies Creld1 as a gatekeeper of somatosensation

The paper identifies Creld1 as a master regulator of somatosensation through postnatal CRISPR screening and behavioral assays in mice.

A vagal gut-brain axis for feeding induced gastric secretion

The paper identifies cell-type-specific vagal and enteric circuits that control meal-induced gastric secretion and shows segregation of secretory and motor functions.

Automatically Defining Protein Words for Diverse Functional Predictions Based on Attention Analysis of a Protein Language Model

The paper introduces a toolkit using protein language models to define 'protein words' for functional prediction, outperforming motif-based methods across multiple tasks.

A disease mutation reveals a non-swapped pore and rewired gating cycle of the mechanically activated PIEZO1 channel

This paper investigates the structural and functional changes in the PIEZO1-R2482H mutant, revealing a non-swapped pore and altered gating cycle that explain its heightened mechanosensitivity and slowed inactivation.

Structural Role of Stomatin in Organizing Functional Membrane Microdomains

This study determines the cryo-EM structure of stomatin, revealing its role in organizing functional membrane microdomains and identifying associated proteins involved in cell migration and vesicle trafficking.

The fetal hydrops-associated single-residue mutation L322P abolishes mechanical but not chemical activation of the PIEZO1 ion channel

The paper identifies a mutation in PIEZO1 that abolishes mechanical activation but not chemical activation, showing a direct link between mechanosensitivity and fetal hydrops.

Central pore-opening structure and gating of the mechanosensitive PIEZO1 channel

This study defines the structural states and curvature-based activation/inactivation mechanisms of PIEZO1 using a mutant and molecular dynamics simulations.

Tethering Piezo channels to the actin cytoskeleton for mechanogating via the E-cadherin-β-catenin mechanotransduction complex

This paper identifies how Piezo1 channels are tethered to the actin cytoskeleton via the E-cadherin-β-catenin complex, enabling mechanogating through direct force transmission.

Piezo2 mediates ultrasonic hearing via cochlear outer hair cells in mice

This study shows that Piezo2 in outer hair cells is essential for ultrasonic hearing in mice, but not for low-frequency hearing.