Minoo Ashtiani

The paper identifies a plant-derived peptide, SPAFESTWDILK, as a potential inhibitor of the MDM2-p53 interaction through computational screening and multi-method evaluation.

This study shows that depletion of RUNX1::RUNX1T1 in AML cells reduces stemness and promotes differentiation into granulocytic and eosinophilic/mast cell-like populations.

This study evaluates CD19 expression in pediatric AML and shows that CD19-directed immunotherapies are effective against CD19+ AML, similar to their efficacy in BCP-ALL.

IMMAN is an R/Bioconductor package that reconstructs interolog protein networks by integrating PPINs and enables conservation analysis across species for protein function prediction.

CINNA compares centrality measures to identify the most informative nodes in networks using dimensionality reduction.

The paper systematically evaluates centrality measures in yeast protein-protein interaction networks to identify which measures best predict influential proteins.