ATGL-mediated lipolysis is essential for myocellular mitochondrial function and augments PPARδ-induced improvements in mitochondrial respiration
Anne Gemmink, Tineke van de Weijer, Gert Schaart, Gernot F. Grabner, Esther Moonen‐Kornips, Kèvin Knoops, Rudolf Zechner, Martina Schweiger, Matthijs K. C. Hesselink
The paper shows that ATGL-mediated lipolysis is essential for mitochondrial function and that PPARδ activation can improve mitochondrial respiration in myotubes with dysfunctional ATGL.
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · Nov 11, 2025Peer-reviewedPhysiology