Martina Schweiger

Combined AMPK activation and ghrelin ameliorate cancer cachexia through complementary effects on energy homeostasis, inflammation, and wasting

This study shows that combining AMPK activation with ghrelin improves cachexia by enhancing energy balance, reducing inflammation, and preventing muscle and fat loss.

Fibroblast-derived thrombospondin-1 shapes macrophage polarization in advanced human co-culture models

This study uses advanced human co-culture models to show that fibroblast-derived thrombospondin-1 drives macrophage metabolic remodeling and polarization in tumor environments.

ATGL-mediated lipolysis is essential for myocellular mitochondrial function and augments PPARδ-induced improvements in mitochondrial respiration

The paper shows that ATGL-mediated lipolysis is essential for mitochondrial function and that PPARδ activation can improve mitochondrial respiration in myotubes with dysfunctional ATGL.

CD8+ T cells regulate the bioenergetic reprogramming of lymphoid organs and the heart during viral infection

This study shows CD8+ T cells drive energy substrate redistribution between lymphoid organs and the heart during viral infection, with metabolic adaptations affecting cardiac function.

White adipose tissue browning preserves UCP1-dependent nonshivering thermogenesis upon brown-adipocyte specific lipase-deficiency

The paper shows that browning of white adipose tissue maintains UCP1-dependent thermogenesis despite loss of lipases in brown adipocytes.

Computational metabolic modeling unveils gut microbiomes role in metabolic shifts during murine cancer cachexia

This study identifies cachexia-associated microbial metabolites using computational modeling and metabolomic analyses in a murine cancer model.

Genome-wide scan and fine-mapping of rare nonsynonymous associations implicates intracellular lipolysis genes in fat distribution and cardio-metabolic risk

This study identifies rare variant associations with fat distribution and cardio-metabolic risk, implicating intracellular lipolysis genes in these traits.