Structural basis of GIRK2 channel modulation by cholesterol and PIP2
Yamuna Kalyani Mathiharan, Ian W. Glaaser, Yulin Zhao, Michael J. Robertson, Georgios Skiniotis, Paul A. Slesinger
The paper presents cryoEM structures of GIRK2 with and without cholesterol analog and PIP2, revealing how CHS modulates channel function by interacting with PIP2 in the transmembrane domain.
Cell Reports · Aug 1, 2021Peer-reviewedNeuroscience