Michael J. Robertson

This study identifies a new family of hookworm peptides that mimic the chordate gut-brain hormone neurotensin, showing structural and functional similarity to modulate gut function.

The paper identifies prey-specific toxins in cephalopod venom, including neurotensin-mimicking peptides that target fish, revealing an evolutionary strategy for broad venom activity.

The paper designs rigid protein fiducials using generative design and deep learning to enable cryoEM visualization of GPCR conformational states, validated with four GPCR inactive structures.

The paper uses cryo-EM to capture non-equilibrium states of the μ-opioid receptor bound to different ligands, revealing ligand-dependent conformational dynamics and G-protein activation differences.

The paper introduces a deep learning tool called Metric Ion Classification (MIC) to classify ions and waters in cryo-EM and x-ray crystallography structures, identifying mismodeled ions in the PDB.

This paper uses computational methods to model how nitazene derivatives bind to the mu-opioid receptor, identifying key binding modes and interactions.

The paper presents cryoEM structures of GIRK2 with and without cholesterol analog and PIP2, revealing how CHS modulates channel function by interacting with PIP2 in the transmembrane domain.

The paper presents structures of GABAB receptor dimers and homomers, revealing the role of ECL2 in ligand binding and G protein activation.