Author

Ian W. Glaaser

Icahn School of Medicine at Mount SinaiORCID 0000-0003-2478-6602Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Assay:electrophysiology· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

Paul A. SlesingeriD· 2 shared Avner SchlessingeriD· 1 shared Georgios SkiniotisiD· 1 shared Ha NguyeniD· 1 shared Jonathan W. MountiD· 1 shared Keino HutchinsoniD· 1 shared Michael J. RobertsoniD· 1 shared Peng YuaniD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiophysics

Paul A. SlesingerORCID

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2 papers

Recent·Most cited

BiophysicsbioRxivPreprintFeb 14, 2025

Key residue Unlocks Dual PIP2-Dependent and Independent Gating in G Protein-Gated Inwardly Rectifying Potassium Channels

Ha Nguyen, Jonathan W. Mount, Keino Hutchinson…·Paul A. Slesinger

The paper identifies R92 as a key residue in GIRK2 channels that modulates both PIP2-dependent and independent gating mechanisms through experimental and structural analyses.

DOI 10.1101/2025.02.14.637896

humanelectrophysiology

𝕏 PostBluesky

NeuroscienceCell ReportsPeer-reviewedAug 1, 2021

Structural basis of GIRK2 channel modulation by cholesterol and PIP2

Yamuna Kalyani Mathiharan, Ian W. Glaaser, Yulin Zhao…·Paul A. Slesinger

The paper presents cryoEM structures of GIRK2 with and without cholesterol analog and PIP2, revealing how CHS modulates channel function by interacting with PIP2 in the transmembrane domain.

54 citations

experimental assay

𝕏 PostBluesky