Kim Lam Chiok

This study compares SARS-CoV-2 and MERS-CoV infection dynamics and antiviral responses in primary lung organoid-derived monolayers and air-liquid interface cultures, finding that ALI cultures better capture viral infection and immune responses.

This study identifies extracellular ISG15 as a soluble antiviral factor that promotes IFN-independent ISGylation through integrin-FAK pathway activation during virus infection.