Author

Zihao Song

University of WashingtonORCID 0000-0002-2899-257XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Assay:protein structure· 2 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:protein design· 1 Approach:statistical model· 1

Frequent Co-Authors

David A. BakeriD· 2 shared A G MurrayiD· 1 shared Alex KangiD· 1 shared Amit GauriD· 1 shared Andrei MihutiD· 1 shared Asim K. BeraiD· 1 shared Brian CoventryiD· 1 shared Caixuan LiuiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiochemistry

David A. BakerORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintSep 9, 2026

RFOptimization: Guiding Design Optimization with All-Atom Structure Prediction

Odin Zhang, Jiaqi Wang, Tuscan Rock Thompson…·David A. Baker

RFOptimization improves all-atom biomolecular binder design by combining gradient-guided sequence optimization with orthogonal predictors to enhance in silico success rates.

DOI 10.64898/2026.09.04.749184

protein structuredeep learning

𝕏 PostBluesky

BiochemistrySciencePeer-reviewedJul 17, 2025

Design of intrinsically disordered region binding proteins

Kejia Wu, Hanlun Jiang, Derrick R. Hicks…·David A. Baker

The paper designs proteins that bind intrinsically disordered regions with high affinity and specificity across diverse targets.

123 citationstop 1%

protein structuredeep learning

𝕏 PostBluesky