Inflammatory restraint and membrane lipid integrity protect hematopoietic stem cells under stress
Ayano Yahagi, Haruka Okabe-Kitajima, Makiko Mochizuki‐Kashio, Kyoko Komai, Takayoshi Matsumura, Terumasa Umemoto, Mikiro Nawa, Fumio Nakamura, Takayuki Yoshimoto, Kohsuke Kanekura, Stephanie Zhi-Juan Xie, Keiyo Takubo, Toshio Suda, Ayako Nakamura‐Ishizu
This study shows that THPO protects HSCs from inflammatory stress by maintaining membrane lipid integrity and suppressing STAT1-driven pyroptosis.
bioRxiv · Aug 25, 2026 · PreprintCell Biology