Author

Shenela Lakhani

Weill Cornell MedicineORCID 0000-0002-2908-950XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:mouse· 1

Frequent Co-Authors

Caroline Alayne PearsoniD· 1 shared Chengbing WangiD· 1 shared Christophe Michel RaynaudiD· 1 shared Clarissa RoccaiD· 1 shared Csaba KonràdiD· 1 shared Eric James MallackiD· 1 shared Faisal Zafar· 1 shared Giovanni ManfrediiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperNeuroscience

Caroline Alayne PearsonORCID

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2 papers

Recent·Most cited

Mitochondrial dysfunction precedes neurodegeneration in DRPLA patient-derived neurons, and phenylbutyrate improves survival.

Njoud Al-Naama, Csaba Konràd, Shimaa Sherif, Christophe Michel Raynaud, Chengbing Wang, Shenela Lakhani, Giovanni Manfredi, Caroline Alayne Pearson, Margaret Elizabeth Ross

This study shows mitochondrial dysfunction and oxidative stress occur before neuronal loss in DRPLA patient-derived neurons, and phenylbutyrate treatment improves survival.

bioRxiv · Sep 2, 2025 · PreprintNeuroscience

Human mutations in SLITRK3 implicated in GABAergic synapse development in mice

Stéphanie Efthymiou, Wenyan Han, Muhammad Ilyas, Jun Li, Yichao Yu, Marcello Scala, Nancy T. Malintan, Nikoleta Vavouraki, Kshitij Mankad, Reza Maroofian, Clarissa Rocca, Vincenzo Salpietro, Shenela Lakhani, Eric James Mallack, Timothy Blake Palculict, , Henry Houlden

This study identifies SLITRK3 mutations in humans linked to epileptic encephalopathy and shows their loss-of-function effect in neurons and mice, highlighting a role in synapse development and neurological function.

Frontiers in Molecular Neuroscience · Mar 1, 2024Peer-reviewedGenetics