Wenyan Han

The paper identifies host genetic effects on microbiome composition in rats and finds evidence of indirect genetic effects contributing to missing heritability.

RatXcan extends transcriptome-wide association studies to rats, enabling cross-species integration of GWAS and gene expression data to identify shared genetic mechanisms of complex traits.

The paper genotypes Y and mitochondrial chromosomes in heterogeneous stock rats and finds no significant associations with complex traits, except for gene expression on these chromosomes.

This study identifies SLITRK3 mutations in humans linked to epileptic encephalopathy and shows their loss-of-function effect in neurons and mice, highlighting a role in synapse development and neurological function.

AutoQTL automates QTL analysis and GWAS by applying machine learning to detect both additive and non-additive genetic effects in genetic data.

This study identifies Shisa7 phosphorylation at S405 as critical for GABAAR trafficking and function, leading to altered synaptic inhibition and neurodevelopmental behaviors in mice.