Author

Jennifer L. Orthmann‐Murphy

University of PennsylvaniaORCID 0000-0002-2909-1722Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Research Focus:database / resource· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Cody L. CalliD· 1 shared Deberah S. Goldman· 1 shared Dwight E. BerglesiD· 1 shared Erin E. ChowniD· 1 shared Eunchan BaeiD· 1 shared Gian Carlo Molina-CastroiD· 1 shared Harriet Saxe· 1 shared Hasan Orhan AkmaniD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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1 shared paperNeuroscience

Cody L. CallORCID

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3 papers

Recent·Most cited

Unifying the communities of early-onset glycogen storage disease type IV and adult polyglucosan body disease through a genetic prevalence study of GBE1-related disease

Rebecca L. Koch, Hasan Orhan Akman, Erin E. Chown, Deberah S. Goldman, Jeff Levenson, Qing Ling Lu, Lindsay T. Michalovicz Gill, Matthew Morgan, Jennifer L. Orthmann‐Murphy, Natacha T Pires, Rebecca Reef, Harriet Saxe, Moriel Singer‐Berk, Samantha M. Baxter

This paper estimates the global prevalence of GSD IV and APBD by analyzing GBE1 variants across nine genetic groups, finding 1 in 235,784 individuals are affected.

JIMD Reports · Apr 6, 2026Peer-reviewedGenetic & Genomic Medicine

BOSS: Beta-mixture Unsupervised Oligodendrocytes Segmentation System

Eunchan Bae, Virgilio Gonzenbach, Jennifer L. Orthmann‐Murphy, Russell Taki Shinohara

BOSS segments and tracks oligodendrocytes in 3D images over time with minimal human input, performing similarly to a blinded human observer.

bioRxiv · Jun 17, 2022 · PreprintNeuroscience

Remyelination alters the pattern of myelin in the cerebral cortex

Jennifer L. Orthmann‐Murphy, Cody L. Call, Gian Carlo Molina-Castro, Yu Chen Hsieh, Matthew Neil Rasband, Peter A. Calabresi, Dwight E. Bergles

This study uses in vivo imaging to show that remyelination after oligodendrocyte ablation in mice leads to altered myelin patterns in the cerebral cortex, with impaired regeneration in deeper layers.

eLife · May 27, 2020Peer-reviewedNeuroscience