Amjad Askary

Regenerative base editing enables deep lineage recording

This paper introduces a regenerative molecular recording system called hypercascade that enables deep lineage reconstruction by maintaining a constant mutation rate over time.

Reconstructing signaling history of single cells with imaging-based molecular recording

This paper introduces INSCRIBE, a method to reconstruct single-cell signaling history using imaging, and finds that BMP pathway response is heritable across cell divisions.

Spatial motifs reveal patterns in cellular architecture of complex tissues

The paper introduces a method to detect spatial motifs in tissue maps, revealing previously unrecognized patterns in cell type arrangements in mouse neural tissues.

Lineage motifs: developmental modules for control of cell type proportions

The paper introduces Lineage Motif Analysis (LMA) to identify progenitor states by analyzing lineage trees, revealing spatial and temporal patterns in cell fate commitment across vertebrate development.

osr1 couples intermediate mesoderm cell fate with temporal dynamics of vessel progenitor cell differentiation

The paper shows that osr1 regulates intermediate mesoderm formation and delays vessel progenitor differentiation in zebrafish.

Genome-Wide Analysis of Facial Regionalization in Zebrafish

The paper identifies genes with regional expression in zebrafish cranial neural crest cells and reveals complex regulation by Edn1 in facial development.