Justin Gage Crump

The paper shows how three signaling pathways coordinate to establish distinct cell fates along the oral-aboral axis in the developing zebrafish jaw.

This study identifies neural crest cells as the origin of Ewing sarcoma by developing a zebrafish model and showing EWSR1::FLI1 reprograms these cells to a mesoderm-like state.

The paper traces the embryonic origin of calcitonin-producing cells across vertebrates and finds they derive from pharyngeal endoderm, not neural crest, and identifies homologues in invertebrate chordates.

This study shows retinoic acid signaling suppresses chondrocyte identity during cartilage development and regeneration in zebrafish, with implications for treating Multiple Osteochondromas.

This study shows adult zebrafish can regenerate jaw joint ligaments without scarring through dedifferentiation of ligamentocytes and ECM remodeling, with legumain playing a key role.

The paper uses single-cell RNA sequencing to analyze zebrafish inner ear cells, identifying distinct hair cell and supporting cell subtypes and their spatial organization.

The paper shows that the zebrafish pseudobranch develops from mandibular arch tissues and shares features with gills, supporting the hypothesis that vertebrate jaws evolved from modified gills.

The paper integrates single-cell transcriptome and chromatin accessibility data from zebrafish cranial neural crest cells across their lifetime to identify region-specific chromatin remodeling and lineage-priming factors.

This study maps the cellular diversity of the embryonic mouse coronal suture using single-cell transcriptomics, identifying key markers and cell types involved in suture development and fusion.

The paper shows that osr1 regulates intermediate mesoderm formation and delays vessel progenitor differentiation in zebrafish.

This study investigates the role of Tcf12 in coronal suture development in mice, showing its embryonic requirement in controlling bone growth and suture boundary formation.

The paper identifies Foxc1's role in establishing chromatin accessibility for facial cartilage enhancers during zebrafish development.

This paper shows that FOXC1 mutations in zebrafish cause left-right axis defects and congenital heart defects, similar to human Axenfeld-Rieger syndrome.

The paper identifies a conserved Pou3f3 enhancer that drives divergent gill cover patterns in jawed vertebrates by regulating pharyngeal arch expression.

The paper identifies genes with regional expression in zebrafish cranial neural crest cells and reveals complex regulation by Edn1 in facial development.