Christina Halsey

This study develops a physiological CSF-like medium to culture CNS-ALL cells, revealing autophagy as a critical survival mechanism in the CNS niche.

This paper identifies a metabolic vulnerability in leptomeningeal ALL cells due to thiol scarcity in CSF, making them susceptible to ferroptosis through disruption of selenocysteine biosynthesis and GPX4 activity.

This paper develops bi-specific CAR-iNKT cells targeting CD19 and CD133 for KMT2A-rearranged leukemia, showing superior efficacy over CAR-T in eradicating leptomeningeal disease and inducing remission.

This study identifies miR-93 as a key regulator of KMT2A-rearranged B-ALL survival in the CNS niche through transcriptomic and immune profiling in a murine model.