Author

David Lee Wheeler

National Cancer InstituteORCID 0000-0002-2929-4204Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:DNA methylation· 1 Approach:statistical model· 1 Organism:yeast· 1

Frequent Co-Authors

Michael LichteniD· 2 shared Anura ShodhaniD· 1 shared Catherine S. Harvey· 1 shared Hirohisa Masuda· 1 shared Jasvinder S. AhujaiD· 1 shared Julia Promisel CooperiD· 1 shared Manasi S. ApteiD· 1 shared Martin XaveriD· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 9 mutual co-author links

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2 shared papersGenetics

Michael LichtenORCID

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3 papers

Recent·Most cited

Turning coldspots into hotspots: targeted recruitment of axis protein Hop1 stimulates meiotic recombination in Saccharomyces cerevisiae

Anura Shodhan, Martin Xaver, David Lee Wheeler, Michael Lichten

This study shows that recruiting Hop1 to coldspots increases DSBs and recombination, demonstrating Hop1's sufficiency for DSB formation but not crossover pathway selection.

Genetics · Jul 25, 2022Peer-reviewedGenetics

Repeated strand invasion and extensive branch migration are hallmarks of meiotic recombination

Jasvinder S. Ahuja, Catherine S. Harvey, David Lee Wheeler, Michael Lichten

The paper shows that both noncrossover and crossover meiotic recombination involve synthesis-dependent strand annealing, challenging existing models of recombination mechanisms.

Molecular Cell · Aug 27, 2021Peer-reviewedGenetics

RNAi and Ino80 complex control rate limiting translocation step that moves rDNA to eroding telomeres

Manasi S. Apte, Hirohisa Masuda, David Lee Wheeler, Julia Promisel Cooper

The paper identifies RNAi and Ino80 complex as regulators of a translocation step that enables rDNA to replace telomeres in HAATIrDNA formation.

Nucleic Acids Research · Jul 1, 2021Peer-reviewedMolecular Biology