Michael Lichten

This study maps meiotic Holliday junctions genome-wide using HJSeq, showing directional branch migration during pachytene linked to transcription and the ZMM pathway.

This paper shows that Rad51-mediated interhomolog recombination in budding yeast meiosis is inhibited during Phase 1 to prevent competition with Dmc1, and is promoted by the checkpoint and Pif1 helicase.

This study shows that recruiting Hop1 to coldspots increases DSBs and recombination, demonstrating Hop1's sufficiency for DSB formation but not crossover pathway selection.

The paper shows that both noncrossover and crossover meiotic recombination involve synthesis-dependent strand annealing, challenging existing models of recombination mechanisms.

The paper shows that HA epitope tags in SGS1 mutants impair Sgs1 function and exaggerate phenotypes, suggesting previous studies may have overestimated the impact of SUMOylation defects.

The paper shows that Sgs1-Top3-Rmi1 resolves recombination intermediates in yeast, and its absence leads to DNA damage checkpoint activation and cell cycle arrest.

This study shows that Srs2 helicase is essential for normal meiotic progression and prevents Rad51 aggregate formation, which could disrupt chromosome segregation.

The paper shows that Mlh3 dependence of VDE-initiated crossovers varies with genomic location, and Pch2 influences this dependence across different loci.

The paper shows that chromosome structure determines whether crossover recombination in budding yeast uses MutLγ or not, depending on Hop1 protein levels.