Carolina Gutiérrez

This study enables efficient somatic genome editing in rats to model ER+ breast cancer, showing that rat tumors recapitulate key features of human ER+ breast cancer not observed in mice.

This paper identifies AADAT as a metabolic immune checkpoint in TNBC that promotes immune evasion by regulating malate and CoQ10, and shows that malate supplementation can reverse immunotherapy resistance.

This study uses spatial omics to identify distinct tumor microenvironment profiles in Black and White American TNBC patients, linking them to different immunosuppressive mechanisms and clinical outcomes.