Author

Chandandeep S. Nagi

Baylor College of MedicineORCID 0000-0002-4885-289XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Assay:spatial transcriptomics· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Arun SreekumariD· 2 shared Carolina GutiérreziD· 2 shared Xiang H.-F. ZhangiD· 2 shared Aatish ThennavaniD· 1 shared Ahmed M. ElkhananyiD· 1 shared Alastair Mark ThompsoniD· 1 shared Alexandria Z. BuiD· 1 shared Andrew Davis· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

Arun SreekumarORCID

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4 papers

Recent·Most cited

Rat somatic genome editing enables ER+ breast cancer modeling

Wen Bu, Tobie D. Lee, Meenakshi Anurag, Yongchao Dou, Yunfeng Ding, Zhiao Shi, Alexandria Z. Bu, Lillian He, Chandandeep S. Nagi, Carolina Gutiérrez, Jing Wang, Susan Galloway Hilsenbeck, Chonghui Cheng, Bing Zhang, Shixia Huang, , Yi Li

This study enables efficient somatic genome editing in rats to model ER+ breast cancer, showing that rat tumors recapitulate key features of human ER+ breast cancer not observed in mice.

Proceedings of the National Academy of Sciences · Jun 22, 2026Peer-reviewedCancer Biology

AADAT-Driven Metabolic Control of Malate and CoQ10 Shapes Immune Evasion in Triple-Negative Breast Cancer

Megha Chatterjee, Franklin Gu, Susmita Samanta, Uttam Rasaily, Sai Manohar Thota, Dana Varghese, YUNPING QIU, Lynette Ewura Esi Fordwuo, Hugo J. Villanueva, Mary Kathryn McKenna, Jun Hyoung Park, Weijie Zhang, Lin Hai Tian, Liqun Yu, Badrajee Piyarathna, , Arun Sreekumar

This paper identifies AADAT as a metabolic immune checkpoint in TNBC that promotes immune evasion by regulating malate and CoQ10, and shows that malate supplementation can reverse immunotherapy resistance.

bioRxiv · Jan 30, 2026 · PreprintCancer Biology

Integrating Ambient Mass Spectrometry Imaging and Spatial Transcriptomics on the Same Cancer Tissues to Identify Gene-Metabolite Correlations

Trevor M. Godfrey, Yasmin Shanneik, Wanqiu Zhang, Thao Tran, Nico Verbeeck, Nathan Heath Patterson, Faith E. Jackobs, Chandandeep S. Nagi, Maheshwari Ramineni, Lívia S. Eberlin

The paper integrates spatial metabolomics and spatial transcriptomics on cancer tissues to identify gene-metabolite correlations.

Angewandte Chemie International Edition · Apr 11, 2025Peer-reviewedCancer Biology

A spatially resolved single cell genomic atlas of the adult human breast

Tapsi Kumar, Kevin Nee, Runmin Wei, Siyuan He, Quy Nguyen, Shanshan Bai, Kerrigan Blake, Maren Pein, Yanwen Gong, Emi Sei, Min Shan Hu, Tod D. Casasent, Aatish Thennavan, Jianzhuo Li, Tuan Tran, , Nicholas E. Navin

This paper constructs a comprehensive spatially resolved single-cell genomic atlas of the adult human breast, identifying 11 major cell types and revealing diverse immune and epithelial cell populations.

Nature · Jun 28, 2023Peer-reviewedGenomics